Rethinking treatment for nervous system disorders
Empowering patients to live on their own terms
Who We Are
At its core, Eliem is motivated by the promise of helping people live happier, more fulfilling lives. The Eliem team channels its experience, energy and passion for improving patients’ quality of life by developing life-changing novel therapies for neuronal excitability disorders based on clinically validated mechanisms of action.
Our Approach: Optimizing Treatments for Neuronal Excitability Disorders
Tens of millions of people suffer from central and peripheral nervous system disorders, where an imbalance between excitation and inhibition has disrupted the homeostasis in affected neuronal networks. These disorders include a range of common conditions such as chronic pain, depression, epilepsy and anxiety. Currently available treatments for these conditions often fail to provide adequate control or relief, and they are often poorly tolerated, leaving people unable to live life on their own terms.
Developing improved treatments for patients requires a pragmatic and diligent approach. Equal parts rigorous and agile, the experienced Eliem team strives to make treatments that are more effective, safer and better tolerated than currently available treatments. Leveraging clinically validated mechanisms of action, we are moving steadily and efficiently to develop novel therapeutics for neuronal excitability disorders that deliver enhanced outcomes for patients.
Our Pipeline
Our two lead drug candidates have clinically validated mechanisms of action for neurological diseases and have demonstrated encouraging clinical and preclinical results. We are developing ETX-810 for chronic pain and ETX-155 for major depressive disorder, perimenopausal depression and focal onset seizures. These compounds are designed to dramatically improve on the limitations of existing therapies with the potential to be best-in-class for these conditions with high unmet clinical needs.
Our Experienced Team
The team’s combined expertise in neurological research, clinical development, commercialization and company building are critical for delivering on the promise of bringing innovative therapies to market to provide relief and hope for the millions of patients affected by neurological conditions.
Mark received his M.D. from University of Antwerp, Belgium, Ph.D. (Dr. Med.) in clinical pharmacology from Humboldt University in Berlin, Germany and MBA from University of Michigan.
News
Eliem Therapeutics Provides Program Updates and an Overview of Expected Near-Term Milestones
Eliem Therapeutics Reports Third Quarter Financial and Business Highlights
Careers
We are always looking to grow our team and believe it takes teamwork, trust and tenacity to deliver on the promise of helping patients live happier, more fulfilling lives. If this sounds like you, please indicate which position you are interested in and contact us at Careers US or Careers UK.
We’d love to connect.
Location: Cambridge UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com
About this role:
Joining our growing R&D team, you will provide overall scientific and regulatory leadership of the non-clinical safety strategy within Discovery and IND-stage project teams for small-molecules.
Key Responsibilities:
- Act as the project team representative for non-clinical safety on multidisciplinary project teams
- Develop overall toxicology strategy and plans to support the clinical development plan
- Oversee outsourced preclinical toxicology studies at multiple external Contract Research Organizations (CROs)
- Select appropriate CROs
- In partnership with others on the development team, design the strategy for assessing non-clinical safety for development candidates, including giving strategic advice on timings
- Design & execute investigative toxicology studies, based upon off & on-target safety profiles of the candidate drugs
- Monitor toxicology studies for appropriate conduct, accuracy, and timely execution
- Audit raw data for accuracy, review and finalize reports in partnership with CROs as submission-ready documents for regulatory authorities
- Proactively respond to study issues and resolve problems with study director
- Internal and external communication
- Prepare verbal and written summaries for internal discussions
- Review and/or author toxicology and/or safety pharmacology sections of various regulatory documents (e.g., pre-IND briefing documents, INDs, IBs etc.) and ensure their regulatory compliance
- Represent company at meetings with regulatory agencies
- Present summary data to project teams and Eliem senior leadership
Key Requirements:
Essential:
- BSc or equivalent in toxicology, pharmacology, or a related field
- Significant experience in toxicology small molecule drug development in Biotech/Pharma industry
- Experience in filing multiple INDs
- An in-depth understanding of toxicology and/or toxicologic pathology with experience designing and critically evaluating results of exploratory and GLP-compliant toxicology studies
- Experience in supporting project teams as toxicology representative
- Proven ability to communicate well within a multifunctional drug development team, with excellent oral and written communication skills
- Excellent interpersonal skills and ability to interact with staff at all levels
Desirable:
- Experience in filing NDAs
We offer our employees competitive salary and benefits, including pension (9% employer contribution), life assurance, income protection and private medical insurance.
Note that this role may be offered at Director or Senior Director level dependent on experience.
To apply please send your CV and a covering letter to CareersUK@eliemtx.com, quoting job reference E21/07
Location: remote US or UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic and psychiatric diseases such as depression. Our pipeline has two clinical stage compounds in conditions focused on neuropathic pain, epilepsy, and depression. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com.
About this role:
Joining our growing clinical team to provide medical management and professional medical support for clinical research projects sponsored by Eliem Therapeutics.
Responsibilities:
- Accountable for Medical Governance within a clinical trial, including ensuring the scientific integrity of the data and overall safety of study participants
- Accountable for escalation of clinical safety incidents to the Medical Lead, as appropriate.
- Accountable for providing oversight of the safety of study participants on behalf of the Sponsor during the study and, together with the CRO medical monitor, providing input into aspects of study design that relate to subject safety.
- Working as part of a matrix team providing expert clinical input into study design, protocol development, execution, analysis, and reporting.
- Providing clinical input to regulatory and study documentation (e.g., IB, IND, IMPD, protocol, ICFs, Statistical Analysis Plan and annual safety reporting)
- May attend meetings with regulatory authorities/ethics committees as a clinical representative
Experience/Skills:
- Medical Degree from an accredited institution of Medical Education.
- Minimum 4+ years in the CRO, Pharma or Biotech industry with a medical monitoring or study physician role. This role would suit someone who has worked in the CRO environment and is interested in moving into working within a pharmaceutical company.
- Experience of working within the fields of mood disorders, epilepsy or pain required.
- Valid passport and ability to travel internationally, if required.
- Excellent interpersonal skills and ability to interact with staff at all levels
- Strong organizational and prioritization skills
- Strong verbal and written communication, both with internal and external stakeholders
- Ability to work independently and as part of a team, with emphasis on accuracy and timeliness
- Ability to work successfully across international time zones, which may include working at non-standard business hours
- Proficiency in Microsoft Office products
Note that this role may be offered at Director or Senior Director level dependent on candidate experience.
We offer our employees competitive compensation and benefits, including paid time off, health insurance, life and disability insurance, a 401(k) plan, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Location: Greater Seattle Area, Washington
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com.
About this role:
We are looking for a Staff Accountant to join our growing global Accounting team. This new position is involved in month end close, including the calculation of accruals, fixed asset depreciation, and prepaid expenses. The Staff Accountant will be recording journal entries into the company’s ERP system, performing account reconciliations, and assist in other accounting projects. Additionally, the Staff Accountant is responsible for managing the accounts payable function, including the timely processing, verification, tracking, reporting, and payment of all approved invoices. The Staff Accountant must be self-motivated with an outstanding work ethic. The ideal candidate will have excellent communication and organizational skills, be able to work with cross-functional teams. As a results-oriented professional the Staff Accountant will report directly to the Controller.
Responsibilities:
- Assist with month-end close, including posting journal entries and preparing account reconciliations for accounts such as: cash, AP, expense accruals, prepaids, and fixed assets
- Full cycle accounts payable (entering invoices, processing, paying invoices)
- Verify the accuracy of vendor invoices and employee expense reimbursements
- Manage A/P inbox, responding timely to internal and external emails
- Reconcile A/P accounts and vendor statements, including researching, conducting phone calls and correcting discrepancies
- Maintain W-9 records and prepare annual 1099 reports
- Coordinate monthly reconciliation of corporate credit cards
- Identify, track, and properly account for prepaid expenses
- Assist with gathering documents to support auditors’ requests, when needed
- Support the accounting team on special projects and other responsibilities as needed
- Adhere to and maintain internal control processes surrounding vendor management and invoice processing
- Assist with special projects, initiatives, and system/process improvements as needed
- Ability to streamline processes and implement automation whenever possible
Experience/Skills:
- Bachelor’s degree in Finance or Accounting (preferred)
- Minimum 2 years of Accounts Payable experience; 1 year experience GL Accounting experience
- Strong organization and prioritization skills
- Strong verbal and written communication, both with internal and external stakeholders
- Ability to work independently and as part of a team, with emphasis on accuracy and timeliness
- Strong problem-solving skills, basic accounting principles knowledge, documentation skills, research and resolution skills, data analysis and multi-tasking skills
- Proficiency in Microsoft Office products with advanced Excel skills
- Experience with Concur and/or NetSuite preferred
We offer our employees competitive compensation and benefits, including paid time off, health insurance, life and disability insurance, a 401(k) plan, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Location: Cambridge UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com
About this role:
We have a new opportunity in our expanding Clinical team for a Clinical Study Manager to provide operational support to the clinical trial process, contributing to a wide range of tasks related to site management and/or study management of Eliem sponsored studies, as delegated by senior team members.
Key Responsibilities:
- Provide day-to-day support to senior study managers on global clinical trial activities, such as:
- creating/updating study trackers and timelines
- managing contract executions and filing
- managing investigator sites
- participation at investigator meetings
- co-monitoring of clinical studies
- May be involved in the set-up and management of Eliem Phase 1 sponsored studies, ensuring they are conducted to appropriate corporate and regulatory standards
- Authoring, contributing and review of study documents including protocols, amendments, regulatory documents, informed consent, monitoring reports and study plans
- Ensure TMF filing and maintenance is completed routinely
- Review and track study / vendor invoices, including invoice accuracy, comparison to contract and outstanding payments, communicating variances to senior study managers
- Confirm that all clinical trial documents have been collected to support site initiation
- Coordinate and provide minutes for meetings/conference calls
- Work closely with vendors to track performance, escalating any performance and quality issues
- Interact with internal matrix partners and external partners including Investigators and site staff
- Conduct study file audits, including report and resolution of findings
- Conduct quality control review of documents
- Participate in process improvement initiatives
- May be responsible for supporting multiple studies simultaneously and must prioritize appropriately to meet business needs
Key Requirements:
- Bachelor’s degree, or equivalent relevant experience, in Life Sciences or a related field
- Demonstrable clinical trials experience in the pharmaceutical industry or health related field
- Knowledge of the clinical development process and FDA/ICH/GCP regulations
- Excellent communication skills and attention to detail
- Ability to work well in a team environment
- Excellent attention to detail and quality standards
- Proficient IT skills, including MS Office
We offer our employees competitive salary and benefits, including pension (9% employer contribution), life assurance, income protection and private medical insurance.
To apply please send your CV and a covering letter to CareersUK@eliemtx.com, quoting job reference E22/01
Location: Cambridge, UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and completed its initial public offering in 2021. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com
About this role:
As our clinical studies expand, we are seeking to increase the drug product support within our CMC team. You will be responsible for managing the outsourced manufacturing of compounds within Eliem’s drug product portfolio, including formulation development, preclinical and clinical supplies manufacturing and API specification activities, as well as contributing to the regulatory documentation and audits.
Key Responsibilities:
- To manage CDMO interactions including:
- Development and optimisation of new and existing drug product formulations
- Production of drug product under GMP protocols, including batch record review
- Evaluation of drug product formulations in model studies
- Contribution to creation of drug product relevant IND and IMPD documentation
- Advise on API specification requirements, analytical development, and drug product stability assessment activities
- Contribute to the creation of CMC regulatory documentation and audits relating to Drug Product development and manufacturing activities
- Work closely with the members of the chemistry and development teams to ensure that company development objectives are met, ensuring delivery to agreed specification, quality, and budget
Key Requirements:
- Educated to degree level in a relevant subject area
- Experience of managing drug product development activities
- Broad knowledge of formulation options and delivery mechanisms pertinent to neurology indications, specifically solid and semi-solid oral dosage forms
- A knowledge of standard manufacturing processes relevant to drug product scale-up activities to intended commercial scale
- An understanding and application of key GMP and ICH guidelines relevant for drug product development and manufacture
- Ability to understand and interpret pharmacokinetic and other analytical data to facilitate appropriate product development
- Demonstrated skills in working to solve problems in a matrix team environment
- Accurate and organised
- Ability to work in a remote team environment where required
- Good communication skillsThis role may be filled at Associate Director or Director level, dependent on experience
We offer our employees competitive salary and benefits, including bonus, share options, pension (9% employer contribution), life assurance, income protection and private medical insurance.
To apply please send your CV and a covering letter to CareersUK@eliemtx.com, quoting job reference E22/02
Location: Cambridge, UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and completed its initial public offering in 2021. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com
About this role:
As our clinical studies expand, we are seeking to increase the drug product support within our CMC team. You will be responsible for managing the outsourced manufacturing of compounds within Eliem’s drug product portfolio, including formulation development, preclinical and clinical supplies manufacturing and API specification activities, as well as contributing to the regulatory documentation and audits.
Key Responsibilities:
- To manage CDMO interactions including:
- Development and optimisation of new and existing drug product formulations
- Production of drug product under GMP protocols, including batch record review
- Evaluation of drug product formulations in model studies
- Contribution to creation of drug product relevant IND and IMPD documentation
- Advise on API specification requirements, analytical development, and drug product stability assessment activities
- Contribute to the creation of CMC regulatory documentation and audits relating to Drug Product development and manufacturing activities
- Work closely with the members of the chemistry and development teams to ensure that company development objectives are met, ensuring delivery to agreed specification, quality, and budget
Key Requirements:
- Educated to degree level in a relevant subject area
- Experience of managing drug product development activities
- Broad knowledge of formulation options and delivery mechanisms pertinent to neurology indications, specifically solid and semi-solid oral dosage forms
- A knowledge of standard manufacturing processes relevant to drug product scale-up activities to intended commercial scale
- An understanding and application of key GMP and ICH guidelines relevant for drug product development and manufacture
- Ability to understand and interpret pharmacokinetic and other analytical data to facilitate appropriate product development
- Demonstrated skills in working to solve problems in a matrix team environment
- Accurate and organised
- Ability to work in a remote team environment where required
- Good communication skillsThis role may be filled at Associate Director or Director level, dependent on experience
We offer our employees competitive salary and benefits, including bonus, share options, pension (9% employer contribution), life assurance, income protection and private medical insurance.
To apply please send your CV and a covering letter to CareersUK@eliemtx.com, quoting job reference E22/02
Location: Cambridge UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com
About this role:
We have a new opportunity in our expanding Clinical team for a Clinical Study Manager to provide operational support to the clinical trial process, contributing to a wide range of tasks related to site management and/or study management of Eliem sponsored studies, as delegated by senior team members.
Key Responsibilities:
- Provide day-to-day support to senior study managers on global clinical trial activities, such as:
- creating/updating study trackers and timelines
- managing contract executions and filing
- managing investigator sites
- participation at investigator meetings
- co-monitoring of clinical studies
- May be involved in the set-up and management of Eliem Phase 1 sponsored studies, ensuring they are conducted to appropriate corporate and regulatory standards
- Authoring, contributing and review of study documents including protocols, amendments, regulatory documents, informed consent, monitoring reports and study plans
- Ensure TMF filing and maintenance is completed routinely
- Review and track study / vendor invoices, including invoice accuracy, comparison to contract and outstanding payments, communicating variances to senior study managers
- Confirm that all clinical trial documents have been collected to support site initiation
- Coordinate and provide minutes for meetings/conference calls
- Work closely with vendors to track performance, escalating any performance and quality issues
- Interact with internal matrix partners and external partners including Investigators and site staff
- Conduct study file audits, including report and resolution of findings
- Conduct quality control review of documents
- Participate in process improvement initiatives
- May be responsible for supporting multiple studies simultaneously and must prioritize appropriately to meet business needs
Key Requirements:
- Bachelor’s degree, or equivalent relevant experience, in Life Sciences or a related field
- Demonstrable clinical trials experience in the pharmaceutical industry or health related field
- Knowledge of the clinical development process and FDA/ICH/GCP regulations
- Excellent communication skills and attention to detail
- Ability to work well in a team environment
- Excellent attention to detail and quality standards
- Proficient IT skills, including MS Office
We offer our employees competitive salary and benefits, including pension (9% employer contribution), life assurance, income protection and private medical insurance.
To apply please send your CV and a covering letter to CareersUK@eliemtx.com, quoting job reference E22/01
Location: Greater Seattle Area, Washington
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com.
About this role:
We are looking for a Staff Accountant to join our growing global Accounting team. This new position is involved in month end close, including the calculation of accruals, fixed asset depreciation, and prepaid expenses. The Staff Accountant will be recording journal entries into the company’s ERP system, performing account reconciliations, and assist in other accounting projects. Additionally, the Staff Accountant is responsible for managing the accounts payable function, including the timely processing, verification, tracking, reporting, and payment of all approved invoices. The Staff Accountant must be self-motivated with an outstanding work ethic. The ideal candidate will have excellent communication and organizational skills, be able to work with cross-functional teams. As a results-oriented professional the Staff Accountant will report directly to the Controller.
Responsibilities:
- Assist with month-end close, including posting journal entries and preparing account reconciliations for accounts such as: cash, AP, expense accruals, prepaids, and fixed assets
- Full cycle accounts payable (entering invoices, processing, paying invoices)
- Verify the accuracy of vendor invoices and employee expense reimbursements
- Manage A/P inbox, responding timely to internal and external emails
- Reconcile A/P accounts and vendor statements, including researching, conducting phone calls and correcting discrepancies
- Maintain W-9 records and prepare annual 1099 reports
- Coordinate monthly reconciliation of corporate credit cards
- Identify, track, and properly account for prepaid expenses
- Assist with gathering documents to support auditors’ requests, when needed
- Support the accounting team on special projects and other responsibilities as needed
- Adhere to and maintain internal control processes surrounding vendor management and invoice processing
- Assist with special projects, initiatives, and system/process improvements as needed
- Ability to streamline processes and implement automation whenever possible
Experience/Skills:
- Bachelor’s degree in Finance or Accounting (preferred)
- Minimum 2 years of Accounts Payable experience; 1 year experience GL Accounting experience
- Strong organization and prioritization skills
- Strong verbal and written communication, both with internal and external stakeholders
- Ability to work independently and as part of a team, with emphasis on accuracy and timeliness
- Strong problem-solving skills, basic accounting principles knowledge, documentation skills, research and resolution skills, data analysis and multi-tasking skills
- Proficiency in Microsoft Office products with advanced Excel skills
- Experience with Concur and/or NetSuite preferred
We offer our employees competitive compensation and benefits, including paid time off, health insurance, life and disability insurance, a 401(k) plan, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Location: remote US or UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic and psychiatric diseases such as depression. Our pipeline has two clinical stage compounds in conditions focused on neuropathic pain, epilepsy, and depression. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com.
About this role:
Joining our growing clinical team to provide medical management and professional medical support for clinical research projects sponsored by Eliem Therapeutics.
Responsibilities:
- Accountable for Medical Governance within a clinical trial, including ensuring the scientific integrity of the data and overall safety of study participants
- Accountable for escalation of clinical safety incidents to the Medical Lead, as appropriate.
- Accountable for providing oversight of the safety of study participants on behalf of the Sponsor during the study and, together with the CRO medical monitor, providing input into aspects of study design that relate to subject safety.
- Working as part of a matrix team providing expert clinical input into study design, protocol development, execution, analysis, and reporting.
- Providing clinical input to regulatory and study documentation (e.g., IB, IND, IMPD, protocol, ICFs, Statistical Analysis Plan and annual safety reporting)
- May attend meetings with regulatory authorities/ethics committees as a clinical representative
Experience/Skills:
- Medical Degree from an accredited institution of Medical Education.
- Minimum 4+ years in the CRO, Pharma or Biotech industry with a medical monitoring or study physician role. This role would suit someone who has worked in the CRO environment and is interested in moving into working within a pharmaceutical company.
- Experience of working within the fields of mood disorders, epilepsy or pain required.
- Valid passport and ability to travel internationally, if required.
- Excellent interpersonal skills and ability to interact with staff at all levels
- Strong organizational and prioritization skills
- Strong verbal and written communication, both with internal and external stakeholders
- Ability to work independently and as part of a team, with emphasis on accuracy and timeliness
- Ability to work successfully across international time zones, which may include working at non-standard business hours
- Proficiency in Microsoft Office products
Note that this role may be offered at Director or Senior Director level dependent on candidate experience.
We offer our employees competitive compensation and benefits, including paid time off, health insurance, life and disability insurance, a 401(k) plan, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Location: Cambridge UK
About Eliem:
Eliem Therapeutics is a clinical-stage biotechnology company developing medicines for patients with neurologic diseases. Our pipeline has two clinical stage compounds in conditions focused on pain and other neurological conditions. The company continues to grow its preclinical pipeline in neurology.
Eliem launched in 2018 and recently completed its initial public offering. The company has locations in the Greater Seattle Area, WA and Cambridge, UK. For further information visit our website: https://eliemtx.com
About this role:
Joining our growing R&D team, you will provide overall scientific and regulatory leadership of the non-clinical safety strategy within Discovery and IND-stage project teams for small-molecules.
Key Responsibilities:
- Act as the project team representative for non-clinical safety on multidisciplinary project teams
- Develop overall toxicology strategy and plans to support the clinical development plan
- Oversee outsourced preclinical toxicology studies at multiple external Contract Research Organizations (CROs)
- Select appropriate CROs
- In partnership with others on the development team, design the strategy for assessing non-clinical safety for development candidates, including giving strategic advice on timings
- Design & execute investigative toxicology studies, based upon off & on-target safety profiles of the candidate drugs
- Monitor toxicology studies for appropriate conduct, accuracy, and timely execution
- Audit raw data for accuracy, review and finalize reports in partnership with CROs as submission-ready documents for regulatory authorities
- Proactively respond to study issues and resolve problems with study director
- Internal and external communication
- Prepare verbal and written summaries for internal discussions
- Review and/or author toxicology and/or safety pharmacology sections of various regulatory documents (e.g., pre-IND briefing documents, INDs, IBs etc.) and ensure their regulatory compliance
- Represent company at meetings with regulatory agencies
- Present summary data to project teams and Eliem senior leadership
Key Requirements:
Essential:
- BSc or equivalent in toxicology, pharmacology, or a related field
- Significant experience in toxicology small molecule drug development in Biotech/Pharma industry
- Experience in filing multiple INDs
- An in-depth understanding of toxicology and/or toxicologic pathology with experience designing and critically evaluating results of exploratory and GLP-compliant toxicology studies
- Experience in supporting project teams as toxicology representative
- Proven ability to communicate well within a multifunctional drug development team, with excellent oral and written communication skills
- Excellent interpersonal skills and ability to interact with staff at all levels
Desirable:
- Experience in filing NDAs
We offer our employees competitive salary and benefits, including pension (9% employer contribution), life assurance, income protection and private medical insurance.
Note that this role may be offered at Director or Senior Director level dependent on experience.
To apply please send your CV and a covering letter to CareersUK@eliemtx.com, quoting job reference E21/07
Contact Us
23515 NE Novelty Hill Road, Suite B221 #125
Redmond, WA 98053
Eliem Therapeutics (UK) Ltd: Reg. 11893311
3rd Floor, 1 Ashley Road
Altrincham, Cheshire WA14 2DT