A clinical stage biopharmaceutical company focused on developing therapeutics for autoimmune-driven inflammatory diseases
About Us
Eliem Therapeutics, following the close of the acquisition of Tenet Medicines, will be focused on developing therapeutics for autoimmune-driven inflammatory diseases, including advancing budoprutug, an anti-CD19 antibody designed for a broad range of autoimmune diseases, including systemic lupus erythematosus, immune thrombocytopenia, and membranous nephropathy.
Our Pipeline
Budoprutug, an anti-CD19 mAb, is designed to deplete CD19-positive B cells, including antibody-secreting cells, in order to directly reduce pathogenic autoantibodies. This reduction of autoantibodies has the potential to be disease-modifying in autoantibody-driven diseases, such as SLE, ITP and MN. In a Phase 1b clinical trial of budoprutug in MN, 3 out of 5 (or 60%) of patients that received four doses of budoprutug achieved a complete remission of proteinuria, a primary symptom of MN.
In SLE, one of budoprutug’s lead indications, the underlying pathology involves production of autoantibodies by autoreactive B cells that contribute to inflammation and tissue damage. Because budoprutug is designed to target and deplete CD19-expressing B cells known to produce autoantibodies, the Company believes budoprutug has the potential to treat SLE.
In ITP, the Company believes targeting plasmablasts and plasma cells is likely to decrease the production of autoantibodies, increase platelet count and ameliorate disease. B cell depletion with anti-CD20 targeting mAbs, has demonstrated efficacy in some patients with ITP based on in clinical trials conducted by third parties. For those patients who do not respond to anti-CD20 therapy, the Company believes an anti-CD19 approach, such as budoprutug, may have the ability to further deplete pathogenic CD20-/CD19+ cells.
Our Experienced Team
Aoife brings to Eliem over 20 years of experience leading drug development organizations across a range of stages and therapeutic areas having most recently served as the President and Chief Executive Officer of Synlogic, a clinical stage biotechnology company developing treatments for rare metabolic diseases based on synthetic biology. In that role, she led the organization from early-stage private company to a late-phase public company with internal GMP manufacturing capabilities, pioneering new regulatory pathways for bacterial therapeutics. She joined Synlogic as Chief Medical Officer in 2016 and was promoted to CEO in October 2018. Prior to Synlogic, Dr. Brennan served as Vice President and Head of the Rare Disease Innovation Unit at Biogen, Inc., where she led the global marketing approvals of ALPROLIX®, ELOCTATE® and SPINRAZA® as well as other early-stage programs. She served as a director of Synlogic from October 2018 to March 2024, as a director of Ra Pharmaceuticals, Inc. from Sept 2018 through its acquisition in April 2020 and currently serves as a director of Fibrogen Inc., Cerevance, LLC and Xilio Therapeutics. Dr. Brennan holds a medical degree from Trinity College Dublin, Ireland and completed her post-graduate training in internal medicine, endocrinology and metabolism at the Royal College of Physicians in Ireland. She also completed post-doctoral training in clinical research and metabolism at the Beth Israel Deaconess Medical Center in Boston and is a graduate of the Harvard Medical School Scholars in Clinical Science Program.
Jan is a rheumatologist and clinical immunologist with 20 years of experience in academic research, patient care and teaching, and more than 15 years of experience in the biotech industry spanning translational, preclinical, early and late clinical development. Prior to Eliem, Dr. Hillson was a Partner at Cascadia Drug Development Group providing strategic advisory support, including indication prioritization, investment opportunity diligence, and planning and oversight of therapeutic development with a focus in immunology. Dr. Hillson’s experience in the biotechnology industry includes senior clinical development and leadership roles at ZymoGenetics (acquired by Bristol Myers Squibb), Momenta (acquired by Johnson & Johnson), Chemocentryx (acquired by Amgen), Alpine Immune Sciences, and Provention Bio (acquired by Sanofi), where she was responsible for the design and execution of clinical development plans and trials for multiple therapeutic candidates in autoimmune diseases and immunovirology. Dr. Hillson is currently serving on the Board of Directors for Eledon Pharmaceuticals. Dr. Hillson received her M.D. from Stanford School of Medicine, an M.S. from the California Institute of Technology, an M.S. in Marine Chemistry from Scripps Institute of Oceanography, and a B.S. from Michigan State University.
News
Eliem Therapeutics Announces Additions to its Leadership Team
Eliem Therapeutics Reports Second Quarter Financial Results
By Bob Azelby
More restrictive opioid prescribing guidelines were put in place in a rightful effort to stop a devastating crisis. But this sudden and dramatic change negatively impacted chronic pain patients who were managing their pain through prescription opioids given few other effective options.
Careers
We are always looking to grow our team and believe it takes teamwork, trust and tenacity to deliver on the promise of helping patients live happier, more fulfilling lives. If this sounds like you, please indicate which position you are interested in and contact us at Careers US or Careers UK.
We’d love to connect.
Department: Clinical Operations
Hiring Manager: VP of Clinical Operations
Effective Date: Immediate
Location: Remote
Assignment Status: Full Time
Classification: Salary, Exempt
About Eliem:
Eliem Therapeutics, Inc. is a biotechnology company focused on developing novel therapies for neuronal excitability disorders to address unmet needs in psychiatry, epilepsy, chronic pain, and other disorders of the peripheral and central nervous systems. These disorders often occur when neurons are overly excited or inhibited, leading to an imbalance, and our focus is on restoring homeostasis. We are developing a pipeline of clinically differentiated product candidates focused on validated mechanisms of action with broad therapeutic potential to deliver improved therapeutics for patients with these disorders. Eliem channels its experience, energy, and passion for improving patients’ quality of life to fuel our efforts to develop life-changing novel therapies. At its core, the Eliem team is motivated by the promise of helping patients live happier, more fulfilling lives.
Eliem launched in 2018 and completed its initial public offering in the US in 2021. The company has teams located in both the US and UK. For further information visit our website: https://eliemtx.com.
About this role:
As a Senior Program Manager/Associate Director in Clinical Operations, you will play a pivotal role in driving the success of our clinical research programs. You will leverage your extensive experience in clinical research and development to lead and manage clinical studies across all phases, ensuring compliance with regulatory standards and adherence to Good Clinical Practice (GCP) and Standard Operating Procedures (SOPs). Your strategic oversight will be crucial in managing budgets, timelines, and cross-functional teams, while your strong leadership and communication skills will foster collaboration and innovation. This role demands a deep understanding of clinical development processes, exceptional problem-solving abilities, and the capacity to oversee multiple projects simultaneously. Your contributions will be instrumental in advancing our clinical programs and achieving our organizational goals.
Key Responsibilities
- Act as the clinical operations representative on project teams, with support from senior team members as needed.
- Apply clinical development and operational knowledge to translate research ideas into high-quality clinical studies.
- Manage clinical studies to ensure they meet corporate and regulatory standards.
Additional Responsibilities
- Lead clinical operations on project teams, with support from senior members as required.
- Coordinate and manage Clinical Team meetings to support projects.
- Set up and manage clinical studies, ensuring compliance with regulatory and quality standards, GCP, and SOPs. This includes oversight of clinical conduct, drug supply, regulatory submissions, data management, and statistical activities through to clinical study report finalization.
- Oversee and manage CROs responsible for delegated tasks, including clinical conduct, drug supply, regulatory, data management, and statistical activities.
- Manage clinical budgets and timelines across projects, ensuring budgets and schedules are met.
- Author key documents, including protocols and regulatory submissions, in collaboration with the Chief Medical Officer and other clinical team members.
- Review and interpret clinical data in conjunction with the study team.
- Provide input into program and regulatory documents as required.
- Provide accurate, current reports to senior leadership on the status of clinical trials (monthly, quarterly, as needed) as a member of the Clinical Team.
- Assist in the development and optimization of processes for Clinical Operations (SOPs) as a member of the Eliem Quality Team.
Experience
- Bachelor’s degree in Life Sciences, or a related field. A master’s degree is often preferred.
- Minimum of 10 years of experience in clinical research and development, with a strong emphasis on managing clinical studies across all phases.
- PMP or equivalent certifications are desirable
- Proven track record of leading clinical operations and managing cross-functional teams.
- Experience with regulatory submissions and compliance with GCP and SOPs.
- Demonstrated ability to manage clinical budgets and timelines effectively.
- Strong understanding of clinical development processes and industry best practices.
- Excellent leadership and team management skills.
- Proficiency in project management and the ability to oversee multiple projects simultaneously.
- Strong analytical and problem-solving skills.
- Effective communication and interpersonal skills to work collaboratively with various stakeholders.
- Ability to provide strategic input and drive quality within clinical programs.
The physical demands described here are representative of those that must be met by an employee to successfully perform the primary functions of this job. This role is performed primarily from home with occasional site visits, the conditions of which may vary.
- Work is normally performed in a home or professional indoor office work environment
- Continuously remain in a sedentary position the majority of the day – employees are expected to create and maintain an ergonomic workstation
- Operate a computer with time spent looking at monitor about 85% of the time
- Communicate and exchange accurate information clearly with others
- Continuously able to interpret visual content displayed on a digital screen
- Very limited to no exposure to physical risk
- Very limited to no physical effort required
- Walk or stand occasionally
- Use hands, wrists, and fingers to manipulate, control, or feel objects, tools, or equipment
- Move about inside the office to access file cabinets, office machinery, etc.
- Must be able to lift, move, push, pull, or otherwise manipulate objects of at least 10 pounds
The base pay range for this position at commencement of employment is expected to be $175,000 – 250,00 annually. Base salary offered may vary depending on individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, generous paid time off and paid holiday, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Department: Operations
Hiring Manager: CEO/COO
Effective Date: Immediate
Location: On-Site, Wellesley in Metro West
Assignment Status: Full Time
Classification: Non-Exempt, Salary
About Eliem:
Eliem Therapeutics is a clinical stage biotechnology company focused on developing therapeutics for autoimmune-driven inflammatory diseases, including advancing budoprutug, an anti-CD19 antibody designed for a broad range of autoimmune diseases, including systemic lupus erythematosus, lupus nephritis, immune thrombocytopenia and membranous nephropathy. Eliem channels its experience, energy, and passion for improving patients’ quality of life to fuel our efforts to develop life-changing novel therapies. At its core, the Eliem team is motivated by the promise of helping patients live happier, more fulfilling lives.
Eliem launched in 2018 and completed its initial public offering in the US in 2021. The company has teams located throughout the US with hubs in the Boston area and Seattle. For further information visit our website: https://eliemtx.com.
About this role:
The Office Manager/Administrative Assistant plays a key role in ensuring the smooth operation of the office and providing administrative support to various departments. This position involves managing office activities, coordinating administrative tasks, and assisting with organizational needs to enhance overall efficiency. Successful execution of this role demands exceptional organizational abilities, keen attention to detail, and the capacity to handle multiple tasks in a fast-paced environment.
Responsibilities
- Responsible for the day-to-day management of office facilities, including:
- Ensure office equipment is properly maintained, serviced, and troubleshooting equipment issues, overseeing supplies, and managing the cleaning crew for a small office space spanning 4000 square feet.
- Manage office supplies inventory, including ordering and restocking as needed.
- Liaise with vendors, service providers, and building management.
- Manage incoming and outgoing communications, including phone calls, emails, and mail.
- Greet and assist visitors, clients, and vendors in a professional manner.
- Providing administrative support to the CEO and senior executives, which includes managing schedules, greeting guests, and handling expense reports and complex travel arrangements.
- Supporting the board and management by providing assistance for a range of meetings and events, including all-hands meetings, internal communications, and holiday parties. Responsibilities include coordinating logistics and resources for company events and activities.
- Support special projects, initiatives and other administrative duties as directed by management.
Experience
- High school diploma or equivalent; Associate’s or Bachelor’s degree in business administration or related field preferred.
- Proven experience as an office manager, administrative assistant, or similar role.
- Proficient in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) and office equipment.
- Strong organizational and multitasking skills with attention to detail.
- Excellent communication and interpersonal skills.
- Ability to maintain confidentiality and handle sensitive information.
- Familiarity with office management procedures and basic HR principles.
The physical demands described here are representative of those that must be met by an employee to successfully perform the primary functions of this job. This role is performed on site at the office facility with occasional site visits to other meeting venues, the conditions of which may vary.
- Work is normally performed in a professional indoor office work environment
- Continuously remain in a sedentary position the majority of the day – employees are expected to create and maintain an ergonomic workstation
- Operate a computer with time spent looking at monitor about 85% of the time
- Communicate and exchange accurate information clearly with others
- Continuously able to interpret visual content displayed on a digital screen
- Very limited to no exposure to physical risk
- Very limited to no physical effort required
- Walk or stand occasionally
- Use hands, wrists, and fingers to manipulate, control, or feel objects, tools, or equipment
- Move about inside the office to access file cabinets, office machinery, etc.
- Must be able to lift, move, push, pull, or otherwise manipulate objects of at least 10 pounds
The base pay range for this position at commencement of employment is expected to be $65,000 – $85,000 annually. Base salary offered may vary depending on individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, generous paid time off and paid holiday, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Department: Operations
Hiring Manager: CEO/COO
Effective Date: Immediate
Location: On-Site, Wellesley in Metro West
Assignment Status: Full Time
Classification: Non-Exempt, Salary
About Eliem:
Eliem Therapeutics is a clinical stage biotechnology company focused on developing therapeutics for autoimmune-driven inflammatory diseases, including advancing budoprutug, an anti-CD19 antibody designed for a broad range of autoimmune diseases, including systemic lupus erythematosus, lupus nephritis, immune thrombocytopenia and membranous nephropathy. Eliem channels its experience, energy, and passion for improving patients’ quality of life to fuel our efforts to develop life-changing novel therapies. At its core, the Eliem team is motivated by the promise of helping patients live happier, more fulfilling lives.
Eliem launched in 2018 and completed its initial public offering in the US in 2021. The company has teams located throughout the US with hubs in the Boston area and Seattle. For further information visit our website: https://eliemtx.com.
About this role:
The Office Manager/Administrative Assistant plays a key role in ensuring the smooth operation of the office and providing administrative support to various departments. This position involves managing office activities, coordinating administrative tasks, and assisting with organizational needs to enhance overall efficiency. Successful execution of this role demands exceptional organizational abilities, keen attention to detail, and the capacity to handle multiple tasks in a fast-paced environment.
Responsibilities
- Responsible for the day-to-day management of office facilities, including:
- Ensure office equipment is properly maintained, serviced, and troubleshooting equipment issues, overseeing supplies, and managing the cleaning crew for a small office space spanning 4000 square feet.
- Manage office supplies inventory, including ordering and restocking as needed.
- Liaise with vendors, service providers, and building management.
- Manage incoming and outgoing communications, including phone calls, emails, and mail.
- Greet and assist visitors, clients, and vendors in a professional manner.
- Providing administrative support to the CEO and senior executives, which includes managing schedules, greeting guests, and handling expense reports and complex travel arrangements.
- Supporting the board and management by providing assistance for a range of meetings and events, including all-hands meetings, internal communications, and holiday parties. Responsibilities include coordinating logistics and resources for company events and activities.
- Support special projects, initiatives and other administrative duties as directed by management.
Experience
- High school diploma or equivalent; Associate’s or Bachelor’s degree in business administration or related field preferred.
- Proven experience as an office manager, administrative assistant, or similar role.
- Proficient in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) and office equipment.
- Strong organizational and multitasking skills with attention to detail.
- Excellent communication and interpersonal skills.
- Ability to maintain confidentiality and handle sensitive information.
- Familiarity with office management procedures and basic HR principles.
The physical demands described here are representative of those that must be met by an employee to successfully perform the primary functions of this job. This role is performed on site at the office facility with occasional site visits to other meeting venues, the conditions of which may vary.
- Work is normally performed in a professional indoor office work environment
- Continuously remain in a sedentary position the majority of the day – employees are expected to create and maintain an ergonomic workstation
- Operate a computer with time spent looking at monitor about 85% of the time
- Communicate and exchange accurate information clearly with others
- Continuously able to interpret visual content displayed on a digital screen
- Very limited to no exposure to physical risk
- Very limited to no physical effort required
- Walk or stand occasionally
- Use hands, wrists, and fingers to manipulate, control, or feel objects, tools, or equipment
- Move about inside the office to access file cabinets, office machinery, etc.
- Must be able to lift, move, push, pull, or otherwise manipulate objects of at least 10 pounds
The base pay range for this position at commencement of employment is expected to be $65,000 – $85,000 annually. Base salary offered may vary depending on individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, generous paid time off and paid holiday, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Department: Clinical Operations
Hiring Manager: VP of Clinical Operations
Effective Date: Immediate
Location: Remote
Assignment Status: Full Time
Classification: Salary, Exempt
About Eliem:
Eliem Therapeutics, Inc. is a biotechnology company focused on developing novel therapies for neuronal excitability disorders to address unmet needs in psychiatry, epilepsy, chronic pain, and other disorders of the peripheral and central nervous systems. These disorders often occur when neurons are overly excited or inhibited, leading to an imbalance, and our focus is on restoring homeostasis. We are developing a pipeline of clinically differentiated product candidates focused on validated mechanisms of action with broad therapeutic potential to deliver improved therapeutics for patients with these disorders. Eliem channels its experience, energy, and passion for improving patients’ quality of life to fuel our efforts to develop life-changing novel therapies. At its core, the Eliem team is motivated by the promise of helping patients live happier, more fulfilling lives.
Eliem launched in 2018 and completed its initial public offering in the US in 2021. The company has teams located in both the US and UK. For further information visit our website: https://eliemtx.com.
About this role:
As a Senior Program Manager/Associate Director in Clinical Operations, you will play a pivotal role in driving the success of our clinical research programs. You will leverage your extensive experience in clinical research and development to lead and manage clinical studies across all phases, ensuring compliance with regulatory standards and adherence to Good Clinical Practice (GCP) and Standard Operating Procedures (SOPs). Your strategic oversight will be crucial in managing budgets, timelines, and cross-functional teams, while your strong leadership and communication skills will foster collaboration and innovation. This role demands a deep understanding of clinical development processes, exceptional problem-solving abilities, and the capacity to oversee multiple projects simultaneously. Your contributions will be instrumental in advancing our clinical programs and achieving our organizational goals.
Key Responsibilities
- Act as the clinical operations representative on project teams, with support from senior team members as needed.
- Apply clinical development and operational knowledge to translate research ideas into high-quality clinical studies.
- Manage clinical studies to ensure they meet corporate and regulatory standards.
Additional Responsibilities
- Lead clinical operations on project teams, with support from senior members as required.
- Coordinate and manage Clinical Team meetings to support projects.
- Set up and manage clinical studies, ensuring compliance with regulatory and quality standards, GCP, and SOPs. This includes oversight of clinical conduct, drug supply, regulatory submissions, data management, and statistical activities through to clinical study report finalization.
- Oversee and manage CROs responsible for delegated tasks, including clinical conduct, drug supply, regulatory, data management, and statistical activities.
- Manage clinical budgets and timelines across projects, ensuring budgets and schedules are met.
- Author key documents, including protocols and regulatory submissions, in collaboration with the Chief Medical Officer and other clinical team members.
- Review and interpret clinical data in conjunction with the study team.
- Provide input into program and regulatory documents as required.
- Provide accurate, current reports to senior leadership on the status of clinical trials (monthly, quarterly, as needed) as a member of the Clinical Team.
- Assist in the development and optimization of processes for Clinical Operations (SOPs) as a member of the Eliem Quality Team.
Experience
- Bachelor’s degree in Life Sciences, or a related field. A master’s degree is often preferred.
- Minimum of 10 years of experience in clinical research and development, with a strong emphasis on managing clinical studies across all phases.
- PMP or equivalent certifications are desirable
- Proven track record of leading clinical operations and managing cross-functional teams.
- Experience with regulatory submissions and compliance with GCP and SOPs.
- Demonstrated ability to manage clinical budgets and timelines effectively.
- Strong understanding of clinical development processes and industry best practices.
- Excellent leadership and team management skills.
- Proficiency in project management and the ability to oversee multiple projects simultaneously.
- Strong analytical and problem-solving skills.
- Effective communication and interpersonal skills to work collaboratively with various stakeholders.
- Ability to provide strategic input and drive quality within clinical programs.
The physical demands described here are representative of those that must be met by an employee to successfully perform the primary functions of this job. This role is performed primarily from home with occasional site visits, the conditions of which may vary.
- Work is normally performed in a home or professional indoor office work environment
- Continuously remain in a sedentary position the majority of the day – employees are expected to create and maintain an ergonomic workstation
- Operate a computer with time spent looking at monitor about 85% of the time
- Communicate and exchange accurate information clearly with others
- Continuously able to interpret visual content displayed on a digital screen
- Very limited to no exposure to physical risk
- Very limited to no physical effort required
- Walk or stand occasionally
- Use hands, wrists, and fingers to manipulate, control, or feel objects, tools, or equipment
- Move about inside the office to access file cabinets, office machinery, etc.
- Must be able to lift, move, push, pull, or otherwise manipulate objects of at least 10 pounds
The base pay range for this position at commencement of employment is expected to be $175,000 – 250,00 annually. Base salary offered may vary depending on individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, generous paid time off and paid holiday, and stock options. Qualified candidates are encouraged to forward their resumes to CareersUS@eliemtx.com.
Eliem is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.
Contact Us
PMB #117
2801 Centerville Road, 1st Floor
Wilmington, DE 19808-1609
Eliem Therapeutics (UK) Ltd: Reg. 11893311
3rd Floor, 1 Ashley Road
Altrincham, Cheshire WA14 2DT